Spectrophotometric Determination of Paracetamol Drug via Charge-Transfer Complex Formation

Hadeel M. Dawood; Hassan T. Abdulsahib; Atared F. Hassan

المؤلفون

Hadeel M. Dawood Department of Chemistry, College of Science, University of Basrah, Basrah, Iraq المؤلف
Hassan T. Abdulsahib Department of Chemistry, College of Science, University of Basrah, Basrah, Iraq المؤلف
Atared F. Hassan Department of Chemistry, College of Science, University of Basrah, Basrah, Iraq المؤلف

الكلمات المفتاحية:

 Pharmaceutical, Spectrophotometric, paracetamol, Charge- transfer.

الملخص

An Accurate, simple, rapid, inexpensive and sensitive method has been applied for the spectrophotometric determination of paracetamol, in bulk sample and dosage form, depending on the formed charge- transfer complex between cited drug and, Tetracyanoethylene (TCNE) as a chromogenic reagent. The formed complex shows absorbance maxima at 410 nm against reagent blank. The calibration graph is linear in the ranges of (1.0 - 22.0) µg.mL^-1 with detection limit of 0.195 µg.mL^-1. The results show the absence of interferences from the excipients on the determination of the drug. Therefore, the proposed method has been successfully applied for the determination of paracetamol in pharmaceutical preparations.

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